Question

If my Pokémon has a nature that lowers its Def., Can I make up the stat loss by giving it 252 def EVs?

Comments

If you're playing competitive, the best thing to do in either case is breed a Pokemon with a nature you actually want.

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Natures multiply stats, which means that a Pokemon with higher physical defense will be more affected by a defense lowering nature. So a level 100 Chansey with perfect IVs needs 24 EVs to cancel out the stat loss, while a Shuckle would need 224 EVs. You can use https://calc.pokemonshowdown.com/?gen=8 to calculate stats.
SwSh also has mints, which will work better than whatever you're trying to do.

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It would be easier just to buy a mint in the Battle Tower than to try to combat the bad nature your Pokemon has

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Ok thanks

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sumwun I wish you would've typed that in the answer spot. Lol. That's definitely the best answer and helps alot

Answer 1

Natures multiply stats, which means that a Pokemon with higher physical defense will be more affected by a defense lowering nature. So a level 100 Chansey with perfect IVs needs 24 EVs to cancel out the stat loss, while a Shuckle would need 224 EVs. You can use this calculator to calculate stats.
source
SwSh also has mints, which will work better than whatever you're trying to do.
source