U-Turn is not that powerful.
Tho,with 4x Weakness,Choice Band,Atk based Genesect attacks,i'm pretty sure you can.
Tho,you don't need to worry that much since Genesect is not weak to Zarude.
If Zarude does have a Fire attack(which i'm pretty sure he can't learn one.Maybe Hidden Power only),then is much more of a threat.
But,i'm pretty sure you can.