Easily! Shedinja gains a weakness to Bug, Ground, Poison, Grass, Fighting and Normal type attacks in Inverse Battles, so any move of that type will break though Wonder Guard be able to hit Shedinja.
Like with every other Pokemon, Shedinja's weaknesses and resistances are swapped during Inverse Battles; Wonder Guard does not make it an exception to this. Basically, everything that is normally immune to hits it for super effective damage during Inverse Battles, and anything that is ordinarily super effective on will not do any damage to it during an Inverse Battle.